Treasury Secretary Janet Yellen hailed the work done by women in her department as she unveiled the first US banknotes bearing the signature of a female secretary.
The new $1 and $5 bills being printed in Ft. Worth are also the first carrying the signature of a Native American woman — US Treasurer Lynn Malerba. The banknotes will be delivered to the Federal Reserve in December and enter into circulation in January 2023, a Treasury spokesperson said.

per the fed:

>.  For FY 2023, these priorities include producing a new banknote series with the signatures of the new Treasurer and Secretary

so, presumably that means anytime now (as we are already in FY 2023 since oct 1)

given that this is going to be the first time both signatures on currency will be from women, it’ll probably get a big announcement when it does finally come out. and since ‘international women’s day’ is march 8 next year, I’d bet it will be around that time – but that’s just a guess.

Maybe next year we’ll start to see the 2021 series. My experience is the BEP tends to be slow issuing new series.